Keith Bradnam famously likened genome assembly to pizza, the metaphor being that trying to find “the best” pizza is impossible, because people like and want different things when they go out for pizza.
Here are a few other foods that are like genome assembly:
1. Eton Mess
Eton mess is a British dessert where you take a large piece of meringue and crumble it into to tiny pieces, mixing in strawberries and cream. It is, literally, a mess:
I think this one speaks for itself – clearly the spaghetti is the assembly graph, and the mince/cheese are histones/methylated C etc
Famously, when it comes to marmite, people either love it or hate it. The metaphor breaks down because I don’t know anyone who loves genome assembly 🙁
4. “Macaroni” Cheese
I chose “macaroni” cheese to be a metaphor for the mistakes and falsehoods that are seen in all genome assemblies. Perform a google image search for “Macaroni Cheese” and this image comes up:
People: This is not macaroni cheese – it is penne cheese (call me a pedant, but macaroni refers to a specific type/shape of pasta)
Quite simply – they stink and I hate them
Well – that’s all folks – please put other suggestions in the comments!